报告题目： Ubiquitin Signaling in Immune Defense - the magic of forming a chain
报告人： Zhijian Chen , Ph.D.
Professor of Molecular Biology, UT Southwestern Medical Center
Investigator, Howard Hughes Medical Institute
时 间： 2011年5月20日（星期五）下午4点
Investigator, Howard Hughes Medical Institute
时 间： 2011年5月20日（星期五）下午4点
地 点： 医学院综合楼205报告厅
Research Abstract Summary:
Dr. Chen has been taking classical biochemical and genetic approaches on the dissection of two signaling pathways: ubiquitin-mediated activation of protein kinases and antiviral innate immunity. He is the first person to uncover the second function of ubiquitin---cellular signaling function (instead of its conventional proteolytic function). He is also the first person to discover the novel function of mitochondria---cellular antiviral function. He is a regular contributor to publications in Nature, Cell, Genes $ Development, Molecular Cell, Immunity and other top-tier journals. His work has been recognized by several awards including the ‘The Welch Foundation Norman Hackerman Award in Chemical Research’ and ‘The Edith and Peter O’Donnell Award in Science by The Academy of Medicine, Engineering and Science of Texas’.
个人简介：
陈志坚博士，福建安溪人，1981-1985年就读于中国福建师范大学生物系获学士学位；1986-1991年就读于位于布法罗的纽约州立大学并获得博士学位；1991-1992年，在salk学院攻读博士后；1992-1994年在美国的百特药业公司任研究科学家；1994-1997年任ProScript公司高级科学家；1997-2002年任德克萨斯大学西南医学中心分子生物学系助理教授；2002-2005年任德克萨斯大学西南医学中心分子生物学系副教授；2005至今任该系教授同时还担任霍华德·休斯医学研究所研究员。
先后在Science，Nature，Cell，Nature Cell Biology， Molecular Cell，Nature Immunology等发表系列研究论文，其中有17篇学术论文是发表在Science，Nature，Cell杂志上发表。先后获得过安娜富勒奖学金、塞尔学者奖学金、美国癌症协会研究学者、白血病与淋巴癌协会学者、Burroughs Wellcome基金传染病发病机理研究员、达拉斯亚洲商业会议医药特殊贡献奖以及Welch基金颁发的Norman Hackerman奖等荣誉和奖项。
Selected Publications
1. van Oers, N., and Chen, Z.J. (2005). Kinasing and Clipping Down the NF-κB Trail. Science 308, 65-66
2. Seth, R.B., Sun, L., Ea, C., and Chen, Z.J. (2005) Identification and characterization of MAVS: a mitochondrial antiviral signaling protein that activates NF-êB and IRF3. Cell 122, 669-682.
3. Fitzgerald K.A., and Chen, Z.J. (2006) Sorting out Toll signals. Cell 125, 834-836.
4. Gack, M. U., Shin, Y. C., Joo, C. H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., and Jung, J. U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920
5. Chiu, Y-H., Sun, Q., and Chen, Z.J. (2007) E1-L2 activates both ubiquitin and FAT-10. Molecular Cell 27, 1014-
6. Moore, C.B. Bergstralh, D.T., Duncan, J.A. Lei, Y., Morrison, T.E., Accavitti-Loper, M.A., Madden, V.J., Sun, L.,Lich, J.D., Heise, M.T., Chen, Z.J., and Ting., J. P-Y. (2008) NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451, 573-577.
7. Bhoj, V.G., and Chen, Z. J. (2008) Linking retroelements to autoimmunity Cell 134, 569-571.
8. Bhoj, V.G., and Chen, Z. J. (2009) The role of ubiquitination in innate and adaptive immunity. Nature 458, 430-437.
9. Skaug B., Jiang, X., and Chen,Z. J. (2009) The role of ubiquitin in NF-êB Regulatory Pathways. Annu. Rev.Biochem. 78, 769-796.
10. Chiu, Y.H., Macmillan, J.B., and Chen, Z.J. (2009). RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576-591.
11. Xia, Z.P., Sun, L., Chen, X., Pineda, G., Jiang, X., Adhikari, A., Zeng, W., and Chen, Z.J. (2009). Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 461, 114-119.
12. Sun, L., Liu, S., and Chen, Z.J. (2010) SnapShot: Antiviral innate immunity pathways. Cell 140, 436.
13. Dixit, E., Boulant, S., Zhang, Y., Lee, A.S., Odendall, C., Shum, B., Hacohen, N., Chen, Z.J., Whelan, S.P., Fransen,M., NIbert, M. L., Superti-Furga, G., Kagan, J.C. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141, 668-681.
14. Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., and Chen, Z.J. (2010) Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell 141, 315-330.
15. Skaug, B., and Chen, Z.J. (2010) Emerging role of ISG15 in antiviral immunity. Cell 143, 187-190.
