报告题目：The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response
报告人：   陈大华  教授
                 中科院动物所 生殖生物学国家重点实验室副主任
主持人：   冯新华  教授
时    间：  2011年6月10日（星期五）下午4点 
地    点：  医学院综合楼205报告厅 

工作经历：

2008-至今   生殖生物学国家重点实验室副主任

2007-2008   生物膜与膜生物工程国家重点实验室，中科院动物所分室副主任

2005-至今   研究员，博士生导师，中国科学院动物所“百人计划”

2003-2005  Instructor， Department of Molecular Biology， UT Southwestern

2000-2003  Postdoctoral researcher，Department of Molecular Biology， UT Southwestern

教育经历：

1996-1999   博士， 中国科学院植物研究所

1993-1996   硕士， 中国农业大学

1987-1991   学士， 安徽农业大学

Selected Publications：

1.  Wang, H., Mu, Y., Chen, D.* 2011, Effective gene silencing in Drosophila ovarian germline by artificial microRNAs. Cell Research, 21(4):700-3.

2.  Xia, L., Jia, S., Huang, S., Wang, H., Zhu, Y., Mu, Y., Kan, L., Zheng, W., Wu, D., Li, X., Sun, Q., Meng, A. and Chen, D*. 2010, The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell, 143, 978-990.

3.  Chen, DS, Wang, Q., Huang, H., Xia, L., Kan, L., Sun, Q. and Chen, D.* 2009, Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila. Development, 136(24), 4133-4142.

4.  Nishida, k., Okada, T., Kawamura, T., Mituyama, T.,Yoshinori Kawamura, Y., Sachi Inagaki, S., Huang, H., Chen, D., Kodama, T., Siomi , H and Siom, M. 2009 Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. EMBO J, 28(24):3820-31.

5.  Yang, Y., Xu, S., Xia, L., Wang, J., Jin, P.*, and Chen, D.* 2009, The bantam microRNA is associated with Drosophila Fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genetics, 5(4):e1000444.

6.  Chang, S., Wen, S., Chen, D.* and Jin, P.* 2009, Small regulatory RNAs in neurodevelopmental Disorders. Human Molecular Genetics，18(R1):R18-26.

7.  Jiang, X., Xia, L., Chen, DS, Yang, Y., Huang, H., Yang, L., Zhao, Q., Sheng, L., Wang, J., and Chen, D.* 2008, Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smads complexes. Developmental Cell, 14(4):494-506.

8.  Yang, L., Chen, DS, Duan, R., Xia, L., Wang, J., Qurashi, A., Jin, P.* and Chen D.* 2007, Argonaute 1 regulates the fate of germline stem cells in Drosophila. Development，134(23):4265-72

9.  Yang, L., Duan, R., Chen, DS, Wang, J., Chen D.* and Jin, P.* 2007, Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Hum Mol Genet，16(15):1814-20.

10. Chen, D. and McKearin, D. 2005, Gene circuitry controlling a stem cell niche. Current Biology, 15(2):179-84.

11. Chen, D. and McKearin, D. 2003, Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Current Biology, 13(20):1786-91.

12. Chen, D. and McKearin, D. 2003, A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell. Development, 130(6):1159-70.