报告题目：Functional Glycomics in Immunopathology and Immunotherapy
报告人：   Dapeng Zhou, M.D., Ph.D.
                 Assistant Professor
                 University of Texas MD Anderson Cancer Center
主持人：  冯新华  教授
时   间：  2012年10月22日（星期一）下午4点
地   点：  医学院综合楼205报告厅

Abstract：
The interaction of glycoconjugates with their receptors are involved in critical biological processes such as embryonic development, signal transduction, and leukocyte adhesion. Glycoconjugates serve as unique epitopes that are recognized by immune receptors. My group has been devoted to study the biochemistry, genetics, and immunobiology of glyco-epitopes recognized by immune cells, such as the glycolipid ligands for Natural Killer T cells, and the glyco-proteins recognized by B cells. Benefiting from the Ion Trap Mass Spectrometry (IT-MS) which we recently developed, we have been able to discover new glyco-epitopes which are structurally difficult to characterize by conventional methods such as HPLC and antibody staining. In collaboration with synthetic chemists, we have been able to produce these epitopes with defined structural characteristics for biological studies. As a multidisciplinary team with experts on mass spectrometry, synthetic chemistry, drug formulation and diagnostic imaging, we are devoted to explore the mechanisms of immune recognition of glycoconjugates during pathogenesis, and to invent effective methods for diagnosis and therapy.