报告题目：Targeting the PI3K pathway in cancer: mechanistic and therapeutic insights from GEM models
报告人： Jean J. Zhao, Ph.D.
主持人： 冯新华 教授
时 间： 2012年12月11日（星期二）下午4点
地 点： 医学院综合楼205报告厅
Brief Introduction
Jean J. Zhao, Ph.D. , Associate professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School;
Department of Cancer Biology, Dana-Farber Cancer Institute.
Department of Cancer Biology, Dana-Farber Cancer Institute.
Research Abstract
They are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. They have developed a number of experimental systems, including knockout and transgeneic mouse models, synthetic human tumors, and kinome-wide libraries of gain/loss-of-function kinases to understand how kinases work, in order to harness their potential as targets for cancer therapies.
Selected Publications:
1. Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, Lanahan AA, Taylor JM, Holmes C, Hahn WC, Zhao JJ, Iglehart JD, Quackenbush J.Therapeutic implication
2. Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE,
3. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK.PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.Cell Metab. 2010 Jul 4
4. Sopasakis VR, Liu P, Suzuki R, Kondo T, Winnay J, Tran TT, Asano T, Smyth G, Sajan MP, Farese RV, Kahn CR, Zhao JJ.Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.Cell Metab.
5. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK.Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis
