报告题目：Integrative Approaches for Decoding the Function of Long Non-coding RNAs in Human Cancer
报告人：陈轶文 博士
主持人：王立铭 教授
时 间：2014年9月11日（周四）下午4点
地 点：医学院综合楼205报告厅
时 间：2014年9月11日（周四）下午4点
地 点：医学院综合楼205报告厅
报告人简介：
陈轶文博士2000年毕业于复旦大学物理系，2007年在美国North Carolina大学获得博士学位，随后在Harvard Medical School和Dana Farber Cancer Institute做博士后研究，即将在The University of Texas M. D. Anderson Cancer Center任Assistant Professor。
陈博士主要利用生物信息学的方法来阐明长非编码rnas与人类癌症的关系。在Nature、 Nat Method、Genome Biol、 Cancer cell 、Genes Dev、Genome Res、Proc Natl Acad Sci U S A.等国际知名学术期刊发表多篇研究论文并受邀担任多个国际杂志编委。
Abstract:
Cumulatively, ~70% of the human genome are transcribed, whereas only ~1.5% of the genome encodes protein. Long non-coding RNAs (lncRNAs) are RNAs that are longer than 200 base pairs (bps), but with little protein coding capacity. Systematic efforts to catalogue lncRNAs have revealed that the human genome encodes over 10,000 lncRNAs. Although several dozens of lncRNAs have been functionally characterized, little is known about the function of most lncRNAs in normal physiology or disease. Advances in genomic technologies provide unparalleled opportunities to characterize the function of lncRNAs. However, integrating different types of omic datasets to generate testable hypotheses is challenging. In this talk, I will present my recent work on developing and utilizing integrative approaches to systematically identify the clinically relevant and/or functionally important lncRNAs in human cancer as well as to dissect the microRNA-mediated lncRNA regulatory network that influences the expression of cancer driver genes.
