报告题目：Establishment and Maintenance of Histone Modifications
报告人：朱冰 研究员
主持人：何向伟 教授
时 间：2015年9月24日（周四）下午4点
地 点：纳米楼457报告厅
时 间：2015年9月24日（周四）下午4点
地 点：纳米楼457报告厅
报告人简介：
朱冰研究员1999年获中科院上海植物生理研究所获得分子遗传学博士学位，先后在瑞士弗雷德里克-米歇尔研究所以及美国霍华德-休斯医学院从事博士后研究，2006年起在北京生命科学研究所担任研究员和高级研究员，2014年起任中科院生物物理所研究员。
朱冰研究员主要从事表观遗传学研究。其实验室以生物化学及定量质谱学为主要研究手段，结合高通量核酸测序，小鼠模型及化学生物学手段，致力于研究表观遗传修饰模式的建立和维持机制。表观遗传修饰可以像遗传信息一样在细胞分裂的过程中被继承，其分子机制却不明朗。朱冰研究员实验室在这一方向上进行针对性研究，一系列研究工作多次发表在Science、Molecular Cell、PNAS、Genes and Development, EMBO Reports, JBC等杂志上。
讲座摘要：
DNA is unarguably the carrier of genetic information. However, DNA sequence alone cannot explain how hundreds of cell types in a complex multi-cellular organism, such as a human individual can possess distinct transcription programs, while sharing the same genetic information. This is believed to be achieved by fine-tuning our genetic information with a so-called “epigenetic” system. To fulfill the two basic tasks challenging the multi-cellular organisms, epigenetic system must simultaneously offer dual characteristics, “Plasticity & Inheritability”. Plasticity allows the transformation of one genome into hundreds of epigenomes and transcriptomes, whereas inheritability permits the maintenance of every single epigenome and its corresponding transcriptome.
Several histone modifications have been shown to be critical in classic epigenetic phenomena, including Position effect variegation, Polycomb silencing and dosage compensation. How newly deposited histones acquire these modifications during/after DNA replication is vital for understanding the mechanisms of epigenetic inheritance. We attempt to address this important question using combinatory approaches by integrating biochemistry, quantitative mass spectrometry and high-throughput sequencing. In this seminar, I will highlight some of our recent progresses along this direction.
