Publications：

自2023年

Hao, X., Shen, Y., Chen, N., Zhang, W., Valverde, E., Wu, L., Chan, H. L., Xu, Z., Yu, L., Gao, Y., Bado, I., Michie, L. N., Rivas, C. H., Dominguez, L. B., Aguirre, S., Pingel, B. C., Wu, Y. H., Liu, F., Ding, Y., Edwards, D. G., Liu, J., Alexander, A., Ueno, N. T., Hsueh, P. R., Tu, C. Y., Liu, L. C., Chen, S. H., Hung, M. C., Lim, B., and Zhang, X. H. -F. (2023) Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell. 30, 648-664.e8

Zhang, W., Xu, Z., Hao, X., He, T., Li, J., Shen, Y., Liu, K., Gao, Y., Liu, J., Edwards, D., Muscarella, A. M., Wu, L., Yu, L., Xu, L., Chen, X., Wu, Y. H., Bado, I. L., Ding, Y., Aguirre, S., Wang, H., Gugala, Z., Satcher, R. L., Wong, S. T. C., and Zhang, X. H.-F. (2023) Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells. Cancer Discovery, 13(2): 474-495.doi: 10.1158/2159-8290.CD-22-0220

Wu, M., Zhang, X., Zhang, W., Yan, L., Liu, X., Zhang, M., Pan, Y., Lobie, P. E., Han, X., and Zhu, T. (2023) Paracrine secretion of IL8 by breast cancer stem cells promotes therapeutic resistance and metastasis of the bulk tumor cells. Cell Commun. Signal. 2023 211. 21, 1–17

2023年以前

Zhang, W.*, Bado, I. L.*, Hu, J., Wan, Y.-W., Wu, L., Wang, H., Gao, Y., Jeong, H.-H., Xu, Z., Hao, X., Lege, B. M., Al-Ouran, R., Li, L., Li, J., Yu, L., Singh, S., Lo, H. C., Niu, M., Liu, J., Jiang, W., Li, Y., Wong, S. T. C., Cheng, C., Liu, Z., and Zhang, X. H.-F. (2021) The bone microenvironment invigorates metastatic seeds for further dissemination. Cell. 10.1016/j.cell.2021.03.011 (Preview in Developmental Cell, doi: 10.1016/j.devcel.2021.03.029; Research highlight in Nature Reviews Cancer, doi: 10.1038/s41568-021-00370-0; Featured in Cancer Discovery's Research Watch, doi: 10.1158/2159-8290.CD-RW2021-063; Recommended by Faculty Opinions, *co-first author).

Bado, I. L.*, Zhang, W.*, Hu, J., Xu, Z., Wang, H., Sarkar, P., Li, L., Wan, Y.-W., Liu, J., Wu, W., Lo, H. C., Kim, I. S., Singh, S., Janghorban, M., Muscarella, A. M., Goldstein, A., Singh, P., Jeong, H.-H., Liu, C., Schiff, R., Huang, S., Ellis, M. J., Gaber, M. W., Gugala, Z., Liu, Z., and Zhang, X. H.-F. (2021) The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells. Dev. Cell. 56, 1100–1117.e9 (Preview in Developmental Cell, doi: 10.1016/j.devcel.2021.03.029, *co-first author).

Xu, L.*, Liu, X.*, Peng, F.*, Zhang, W.*, Zheng, L., Ding, Y., Gu, T., Lv, K., Wang, J., Ortinau, L., Hu, T., Shi, X., Shi, G., Shang, G., Sun, S., Iwawaki, T., Ji, Y., Li, W., Rosen, J. M., Zhang, X. H. F., Park, D., Adoro, S., Catic, A., Tong, W., Qi, L., Nakada, D., and Chen, X. (2020) Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat. Cell Biol. 10.1038/s41556-020-00581-x (News and Views in Nature Cell Biology, doi: https://doi.org/10.1038/s41556-020-00585-7, * co-first author)

Wang, H.*, Zhang, W.*, Bado, I.*, and Zhang, X. H.-F. (2020) Bone as a New Milieu for Disseminated Tumor Cells: An Overview of Bone Metastasis. in Reference Module in Biomedical Sciences, Elsevier, 10.1016/B978-0-12-801238-3.11548-X * co-first author

Zhang, W., Bado, I., Wang, H., Lo, H. C., and Zhang, X. H. F. (2019) Bone Metastasis: Find Your Niche and Fit in. Trends in Cancer. 5, 95–110

Zhang, W.*, Wu, M.*, Chong, Q.-Y., Zhang, M., Zhang, X., Hu, L., Zhong, Y., Qian, P., Kong, X., Tan, S., Li, G., Ding, K., Lobie, P. E., and Zhu, T. (2018) Loss of Estrogen-Regulated MIR135A1 at 3p21.1 Promotes Tamoxifen Resistance in Breast Cancer. Cancer Res. 78, 4915–4928 * co-first author

Tan, S.*, Li, H.*, Zhang, W.*, Shao, Y., Liu, Y., Guan, H., Wu, J., Kang, Y., Zhao, J., Yu, Q., Gu, Y., Ding, K., Zhang, M., Qian, W., Zhu, Y., Cai, H., Chen, C., Lobie, P. E., Zhao, X., Sun, J., and Zhu, T. (2018) NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression. Oncogene. 37, 4887–4900 * co-first author

Zhang, W., Lo, H. C., and Zhang, X. H. F. (2017) Mapping bone marrow niches of disseminated tumor cells. Sci. China Life Sci. 60, 1125–1132

Zhang, M.*, Zhang, W.*, Wu, Z., Liu, S., Sun, L., Zhong, Y., Zhang, X., Kong, X., Qian, P., Zhang, H., Lobie, P. E., and Zhu, T. (2016) Artemin is hypoxia responsive and promotes oncogenicity and increased tumor initiating capacity in hepatocellular carcinoma. Oncotarget. 7, 3267–82 * co-first author

Zhang, W.*, Qian, P.*, Zhang, X., Zhang, M., Wang, H., Wu, M., Kong, X., Tan, S., Ding, K., Perry, J. K., Wu, Z., Cao, Y., Lobie, P. E., and Zhu, T. (2015) Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer. J. Biol. Chem. 290, 13812–29 * co-first author

Chen, J.*, Zhang, W.*, Zhang, M., Guo, Z., Wang, H., He, M., Xu, P., Zhou, J., Liu, Z., and Chen, Q. (2015) Mn( ii ) mediated degradation of artemisinin based on Fe ₃ O ₄ @MnSiO ₃ -FA nanospheres for cancer therapy in vivo. Nanoscale. 7, 12542–12551 * co-first author

 Tian, Z., Chen, Y., Zhang, W., Wu, K.-L., Wang, C., Gupta, R., Xu, Z., Wu, L., Yu, C., Zhang, X. H.-F.,  and Xiao, H. (2022) Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone. ACS Cent. Sci. 8, 3, 312–321

Wu, M., Zhang, X., Zhang, W., Chiou, Y. S., Qian, W., Liu, X., Zhang, M., Yan, H., Li, S., Li, T., Han, X., Qian, P., Liu, S., Pan, Y., Lobie, P. E., and Zhu, T. (2022) Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat. Commun. 2022 131. 13, 1–16

Tian, Z., Wu, L., Yu, C., Chen, Y., Xu, Z., Bado, I., Loredo, A., Wang, L., Wang, H., Wu, K.-L., Zhang, W., Zhang, X. H.-F., and Xiao, H. (2021) Harnessing the power of antibodies to fight bone metastasis. Sci. Adv. 7, eabf2051

Yue, F., Jiang, W., Ku, A. T., Young, A. I. J., Zhang, W., Souto, E. P., Gao, Y., Yu, Z., Wang, Y., Creighton, C. J., Nagi, C., Wang, T., Hilsenbeck, S. G., Feng, X.-H., Huang, S., Coarfa, C., Zhang, X. H.-F., Liu, Q., Lin, X., and Li, Y. (2021) A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res. 10.1158/0008-5472.can-21-1112

Xu, L., Zhang, W., Zhang, X. H.-F., and Chen, X. (2020) Endoplasmic Reticulum Stress in Bone Metastases. Front. Oncol. 10, 1100

Wang, H., Zhang, W., Bado, I., and Zhang, X. H.-F. (2020) Bone tropism in cancer metastases. Cold Spring Harb. Perspect. Med. 10, 1–17

Muscarella, A. M., Dai, W., Mitchell, P. G., Zhang, W., Wang, H., Jia, L., Stossi, F., Mancini, M. A., Chiu, W., and Zhang, X. H. F. (2020) Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. npj Breast Cancer. 6, 1–12

Lo, H. C., Xu, Z., Kim, I. S., Pingel, B., Aguirre, S., Kodali, S., Liu, J., Zhang, W., Muscarella, A. M., Hein, S. M., Krupnick, A. S., Neilson, J. R., Paust, S., Rosen, J. M., Wang, H., and Zhang, X. H.-F. (2020) Resistance to natural killer cell immunosurveillance confers a selective advantage to polyclonal metastasis. Nat. Cancer. 10.1038/s43018-020-0068-9

Arnold, J. M., Gu, F., Ambati, C. R., Rasaily, U., Ramirez-Pena, E., Joseph, R., Manikkam, M., San Martin, R., Charles, C., Pan, Y., Chatterjee, S. S., Den Hollander, P., Zhang, W., Nagi, C., Sikora, A. G., Rowley, D., Putluri, N., Zhang, X. H. F., Karanam, B., Mani, S. A., and Sreekumar, A. (2020) UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 39, 3089–3101

Gao, Y., Bado, I., Wang, H., Zhang, W., Rosen, J. M., and Zhang, X. H. F. (2019) Metastasis Organotropism: Redefining the Congenial Soil. Dev. Cell. 10.1016/j.devcel.2019.04.012

Zhu, Y., Yang, L., Chong, Q.-Y., Yan, H., Zhang, W., Qian, W., Tan, S., Wu, Z., Lobie, P. E., and Zhu, T. (2019) Long noncoding RNA Linc00460 promotes breast cancer progression by regulating the miR-489-5p/FGF7/AKT axis. Cancer Manag. Res. Volume 11, 5983–6001

Zhang, X., Wu, M., Chong, Q.-Y., Zhang, W., Qian, P., Yan, H., Qian, W., Zhang, M., Lobie, P. E., and Zhu, T. (2018) Amplification of hsa-miR-191/425 locus promotes breast cancer proliferation and metastasis by targeting DICER1. Carcinogenesis. 39, 1506–1516

Pandey, V., Zhang, M., You, M., Zhang, W., Chen, R., Zhang, W., Ma, L., Wu, Z.-S., Zhu, T., Xu, X. Q., and Lobie, P. E. (2018) Expression of two non-mutated genetic elements is sufficient to stimulate oncogenic transformation of human mammary epithelial cells. Cell Death Dis. 9, 1147

Wang, H., Tian, L., Liu, J., Goldstein, A., Bado, I., Zhang, W., Arenkiel, B. R., Li, Z., Yang, M., Du, S., Zhao, H., Rowley, D. R., Wong, S. T. C., Gugala, Z., and Zhang, X. H. F. (2018) The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Cancer Cell. 34, 823–839.e7

Ahmad, A., Zhang, W., Wu, M., Tan, S., and Zhu, T. (2018) Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes. Genes Genomics. 40, 243–251

Tan, S., Ding, K., Chong, Q.-Y., Zhao, J., Liu, Y., Shao, Y., Zhang, Y., Yu, Q., Xiong, Z., Zhang, W., Zhang, M., Li, G., Li, X., Kong, X., Ahmad, A., Wu, Z., Wu, Q., Zhao, X., Lobie, P. E., and Zhu, T. (2017) Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. J. Biol. Chem. 292, 13551–13564

Li, G., Wu, X., Qian, W., Cai, H., Sun, X., Zhang, W., Tan, S., Wu, Z., Qian, P., Ding, K., Lu, X., Zhang, X., Yan, H., Song, H., Guang, S., Wu, Q., Lobie, P. E., Shan, G., and Zhu, T. (2016) CCAR1 5′ UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance. Cell Res. 26, 655–673

Kong, X., Wu, W., Yuan, Y., Pandey, V., Wu, Z., Lu, X., Zhang, W., Chen, Y., Wu, M., Zhang, M., Li, G., Tan, S., Qian, P., Perry, J. K., Lobie, P. E., and Zhu, T. (2016) Human growth hormone and human prolactin function as autocrine/paracrine promoters of progression of hepatocellular carcinoma. Oncotarget. 7, 29465–79

Liu, Y., Chen, C., Qian, P., Lu, X., Sun, B., Zhang, X., Wang, L., Gao, X., Li, H., Chen, Z., Tang, J., Zhang, W., Dong, J., Bai, R., Lobie, P. E., Wu, Q., Liu, S., Zhang, H., Zhao, F., Wicha, M. S., Zhu, T., and Zhao, Y. (2015) Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Nat. Commun. 6, 5988

Chen, J., Zhang, W.-J., Guo, Z., Wang, H.-B., Wang, D.-D., Zhou, J.-J., and Chen, Q.-W. (2015) pH-Responsive Iron Manganese Silicate Nanoparticles as T ₁ - T ₂ * Dual-Modal Imaging Probes for Tumor Diagnosis. ACS Appl. Mater. Interfaces. 7, 5373–5383

Tan, S., Ding, K., Li, R., Zhang, W., Li, G., Kong, X., Qian, P., Lobie, P. E., and Zhu, T. (2014) Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2. Breast Cancer Res. 16, R40

Chen, J., Guo, Z., Wang, H.-B., Zhou, J.-J., Zhang, W.-J., and Chen, Q.-W. (2014) Multifunctional mesoporous nanoparticles as pH-responsive Fe2+ reservoirs and artemisinin vehicles for synergistic inhibition of tumor growth. Biomaterials. 35, 6498–6507

Qian, P., Banerjee, A., Wu, Z.-S., Zhang, X., Wang, H., Pandey, V., Zhang, W.-J., Lv, X.-F., Tan, S., Lobie, P. E., and Zhu, T. (2012) Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells. Cancer Res. 72, 6036–50

Kong, X., Li, G., Yuan, Y., He, Y., Wu, X., Zhang, W., Wu, Z., Chen, T., Wu, W., Lobie, P. E., and Zhu, T. (2012) MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression. PLoS One. 7, e41523

Qian, P., Zuo, Z., Wu, Z., Meng, X., Li, G., Wu, Z., Zhang, W., Tan, S., Pandey, V., Yao, Y., Wang, P., Zhao, L., Wang, J., Wu, Q., Song, E., Lobie, P. E., Yin, Z., and Zhu, T. (2011) Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 71, 6463–74