Pengfei Zhang, Ying Fan, Heng Ru, Li Wang, Venkat G. Magupalli, Susan S. Taylor, Dario R. Alessi, Hao Wu#. Crystal structure of the WD40 domain dimer of LRRK2. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jan 29;116(5):1579-1584.
Heng Ru#, Pengfei Zhang and Hao Wu#, Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination. Current Opinion in Structural Biology. 2018 Dec; 53: 178-186.
Heng Ru*, Wei Mi*, Pengfei Zhang, David G. Schatz, Maofu Liao and Hao Wu, DNA Melting Initiates the RAG Catalytic Pathway. Nature Structural and Molecular Biology. 2018 Aug; 25(8): 732-742.
This paper has been recommended by F1000Prime (https://f1000.com/prime/733721293) and highlighted by the News and Views of the Nature Structural and Molecular Biology Journal (https://www.nature.com/articles/s41594-018-0107-8).
Yu Nee Lee, Francesco Frugoni, Kerry Dobbs, Irit Tirosh, Likun Du, Francesca A Ververs, Heng Ru, Lisa Ott de Bruin, Mehdi Adeli, Jacob H Bleesing, David Buchbinder, Manish J Butte, Caterina Cancrini, Karin Chen, Sharon Choo, Reem A Elfeky, Andrea Finocchi, Ramsay L Fuleihan, Andrew R Gennery, Dalia H El-Ghoneimy, Lauren A Henderson, Waleed Al-Herz, Elham Hossny, Robert P Nelson, Sung-Yun Pai, Niraj C Patel, Shereen M Reda, Pere Soler-Palacin, Raz Somech, Paolo Palma, Hao Wu, Silvia Giliani, Jolan E Walter, Luigi D Notarangelo, Characterization of T and B cell repertoire diversity in patients with RAG deficiency. Science Immunology. 2016 Dec 16; 1(6): eaah6109
Heng Ru, Melissa G. Chambers, Tian-Min Fu, Alexander B. Tong, Maofu Liao and Hao Wu, Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. 2015 Nov 19; 163(5): 1138-52.
This paper has been recommended by F1000Prime (http://f1000.com/prime/725924229) and Global Medical Discovery (https://globalmedicaldiscovery.com).
Xiangmin Ni*, Heng Ru*, Feng Ma*, Lixia Zhao*, Neil Shaw, Yingang Feng, Wei Ding, Weibin Gong, Qiaofeng Wang, Songying Ouyang, Genhong Cheng and Zhi-Jie Liu, New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16. Journal of Molecular Cell Biology. 2015 Aug 5 [Epub ahead of print] *co-first authors
Heng Ru*, Pengfei Zhang*, and Hao Wu, Promiscuity is not always bad. Molecular Cell. 2014 Apr 24; 54(2): 208-9. *co-first authors
Lixia Zhao, Tian Hua, Christopher Crowley, Heng Ru, Xiangmin Ni, Neil Shaw, Lianying Jiao, Wei Ding, Lu Qu, Li-Wei Hung, Wei Huang, Lei Liu, Keqiang Ye, Songying Ouyang, Genhong Cheng and Zhi-Jie Liu, Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Research. 2014 Mar; 24(3): 344-58.
Fengfeng Niu, Heng Ru, Wei Ding, Songying Ouyang, and Zhi-Jie Liu, Structural biology study of human TNF receptor associated factor 4 TRAF domain. Protein & Cell. 2013 Sept; 4(9): 687-94.
Heng Ru*, Xiangmin Ni*, Lixia Zhao*, Christopher Crowley, Wei Ding, Li-Wei Hung, Neil Shaw, Genhong Cheng and Zhi-Jie Liu, Structural basis for termination of AIM2-mediated signaling by p202. Cell Research. 2013 Jun; 23(6): 855-8. *co-first authors
Songying Ouyang*, Xianqiang Song*, Yaya Wang*, Heng Ru*, Neil Shaw, Yan Jiang, Fengfeng Niu, Yanping Zhu, Weicheng Qiu, Kislay Parvatiyar, Yang Li, Rongguang Zhang, Genhong Cheng, and Zhi-Jie Liu, Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity. 2012 Jun 29; 36(6): 1073-86. *co-first authors
Heng Ru*, Lixia Zhao*, Wei Ding*, Lianying Jiao, Neil Shaw, Wenguang Liang, Liguo Zhang, Li-Wei Hung, Naohiro Matsugaki, Soichi Wakatsuki, and Zhi-Jie Liu (2012), S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr D Biol Crystallogr. 2012 May; 68(Pt 5): 521-30. *co-first authors
Naoyuki Kondo, Akio Ebiharac, Heng Ru, Seiki Kuramitsu, Aikichi Iwamoto, Zihe Rao, and Zene Matsuda (2009), Thermus thermophilus-derived protein tags that aid in preparation of insoluble viral proteins. Analytical Biochemistry. 2009 Feb 15; 385(2): 278-85.
